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Those participants also tended to walk faster after treatment, suggesting better physical function

Unusual symptoms, like asymmetrically sized tonsils and constant hoarseness, should be checked by a doctor.

If the gap between peak and trough is causing both excess side effects and inadequate efficacy, split dosing addresses both problems simultaneously by flattening the curve in both directions

Elderly patients may be more sensitive to the medications effects and may require slower titration or lower maintenance doses, particularly if they have reduced renal function or are at higher risk for dehydration from gastrointestinal adverse effects